A Nuclear Magnetic Resonance (NMR) spectroscopy device

Welders Aldo H., Fratila Raluca M., Gomez Almagro M. Victoria, Sykora Stanislav,
Patent WO2013095141 (A1), Wageningen Universiteit, 27 June 2013, also published as EP2798363 (A1), and US2015008922 (A1).
First published as NL2008016 (C), Universiteit Twente, 26 June 2013, with priority 22 December 2011.

Device nickname: BBC (Broad-Band-Coil, not requring any tuning)

Abstract

The invention relates to a Nuclear Magnetic Resonance (NMR) spectroscopy device adapted for carrying out 1D and nD homo- and heteronuclear NMR spectroscopy measurements of a plurality of nuclei, comprising an RF coil adapted to transmit RF to and/or receive RF from a measuring volume, wherein the RF coil forms part of a non-tuned radiofrequency circuit. The invention further relates to a method of NMR data acquisition, a method of manufacturing a NMR spectroscopy device and a NMR-device holder.

Full text: WO2013095141A1.pdf (1294 kB).

Cite this patent as:
Welders A.H., Fratila R.M., Gomez Almagro M.V., Sykora S., A Nuclear Magnetic Resonance (NMR) spectroscopy device,
Patent WO 2013/095141, Wageningen Universiteit, June 27, 2013, also published as NL2008016, Universiteit Twente, 26 June 2013.

Various links pertinent to this patent:
- Fratila R.M., Gomez M.V., Sykora S., Velders A., Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil, Nature Communications 5, Article number: 3025 (2014). DOI: 10.1038/ncomms4025. (See also).

Method for nuclear magnetic resonance imaging and relaxometry

Canina Davide, Sykora Stanislav, Ferrante Gianni M., Martini Giuseppe, Golzi Paolo,
Patent EP08103693 (A1), Stelar Srl, 3 December 2008. Also published in Italian as ITMI20070847 (A1), with priority 23 April 2007.

Abstract

A method has been conceived for acquisition and accumulation of a magnetic resonance signal in the presence of signal instability due to field or frequency instability. After submitting an element to be examined to a suitable experiment, a sequence of pulses for example, for measurement of an echo signal (Hahn-echo experiment), the detected signal for each τ is broken up into its Cartesian co-ordinates in an IQ plane, the module of the components is calculated and then the calculated modules are added to each other. By operating on the sum of the calculated modules for each τ in order to at least partly remove the introduced noise, interpolation of the calculated points can be carried out so as to determine a course representative of the acquired and accumulated parameter as a function of τ.

Full text: EP08103693A1.pdf (446 kB).  Note: this patent is no longer enforced (more info).

Cite this patent as:
Canina D., Sykora S., Ferrante G., Martini G., Golzi P., Method for nuclear magnetic resonance imaging and relaxometry,
Patent EP1998185, Stelar Srl, 3 Dec 2008; Patent ITMI20070847, Stelar Srl, 23 April 2007.

Pulse Sequence for Acquiring Nuclear Magnetic Resonance Data
as a function of the Longitudinal Relaxation

Sykora Stanislav, Fantazzini Paola,
Patent WO2007004040 (A1), University of Bologna, 11 January 2007,
first published as ITBO20050445 (A1), University of Bologna, 1 July 2005 (with the same priority).

Method nickname: PERFIDI (Parametrically Enabled Relaxation Filters with Double and multiple Inversion)

Abstract

A nuclear magnetic resonance apparatus (1) acquires nuclear magnetic resonance data from a sample (3) by emitting sequences of radiofrequency pulses (12) consisting, each, of a preparation pulse sequence (14) for bringing the nuclear magnetization of the sample (3) into a desired state, and a subsequent excitation pulse sequence (15) for exciting the nuclear magnetization of the sample (3) , and by accumulating, during accumulation periods (16) which follow the respective sequences of radiofrequency pulses (12) , the response signals (13) emitted by the sample (3) in response to the excitation pulse sequence (15) ; the preparation pulse sequence (14) is composed of a succession of at least two elementary sequences (17) arranged in succession and composed, in their own turn, of respective inversion pulses (18) for inverting longitudinally the nuclear magnetization of the sample (3), followed by respective idle delays (19), during which no radiofrequency pulses are emitted, having respective durations (Di) such as to impose a desired course on the longitudinal relaxation of the nuclear magnetization of the sample (3).

Full text: WO2007004040A1.pdf (1398 kB).  Note: this patent is no longer enforced (more info).

Cite this patent as:
Sykora S., Fantazzini P., Pulse Sequence for Acquiring Nuclear Magnetic Resonance Data as a function of the Longitudinal Relaxation,
Patent WO2007004040, University of Bologna, 11 Jan 2007, published also as ITBO20050445, 1 July 2005.

Various links pertinent to this patent:
- PERFIDI home page on this website.
- Sykora S., Bortolotti V., Fantazzini P., PERFIDI: Parametrically enabled relaxation filters with double and multiple inversion,
Magn. Reson. Imaging 25, 529-532 (2007). DOI: 10.1016/j.mri.2006.12.001. (See also).
- Rinaldin G., Sviluppo del metodo PERFIDI e sua verifica sperimentale per il filtraggio del segnale NMR in sistemi multicomponenti,
Master Thesis, Department of Physics, University of Bologna, In Italian.
- Bortolotti V., Fantazzini P., Gombia M., Greco D., Rinaldin G., Sykora S., PERFIDI filters to suppress and/or quantify relaxation time components in multi-component systems: An example for fat-water systems,
J.Magn.Reson., 206, 219-226 (2010). DOI: 10.1016/j.jmr.2010.07.010. (See also).